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Methyl Methacrylate Shows No Evidence of Respiratory Sensitisation

Peer-reviewed study generated by invitrolize, in collaboration with BASF and Evonik, applying the patented ALIsens® human 3D in vitro alveolar model to assess respiratory sensitisation potential under human-relevant exposure conditions.

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Elsevier_MMA

Why This Study Matters.

  • Methyl methacrylate (MMA) is widely used in industrial, medical, and dental applications

  • Regulatory uncertainty persists due to unreliable human data and legacy test methods

  • No validated tools have been available to identify respiratory sensitisation

  • Critical need to distinguish irritation from true immune-mediated sensitisation

  • This study closes that gap using a human-relevant, mechanistic in vitro approach

Key Results.

  • MMA did not induce molecular or cellular signatures of respiratory sensitisation

  • No activation of immune markers associated with AOP #39

  • Transient stress responses at high doses were clearly separable from sensitisation

  • Clear differentiation from known respiratory sensitizers

Conclusion: MMA should not be classified as a respiratory sensitizer.

Why ALIsens® Changes the Game.

  • Human 3D in vitro reconstruction of the alveolar–capillary barrier

  • Integrated epithelial, endothelial, and immune-relevant cell types

  • Realistic air–liquid interface exposure

  • Clear discrimination between irritation and sensitisation

  • Designed for regulatory relevance and animal-free safety assessment

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Access the full paper and review the scientific approach, validation process and results in detail.

Intended for professionals and research teams working in regulated environments.