---
title: Paper | Methyl Methacrylate No Evidence of Respiratory Sensitisation
description: This study demonstrates that Methyl Methacrylate does not induce respiratory sensitization using a human-relevant 3D in vitro model. Download the paper.
image: https://invitrolize.com/hubfs/Elsevier_MMA.jpg
---

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# Methyl Methacrylate Shows No Evidence of Respiratory Sensitisation

Peer-reviewed study generated by invitrolize, in collaboration with BASF and Evonik, applying the patented ALIsens® human 3D in vitro alveolar model to assess respiratory sensitisation potential under human-relevant exposure conditions.

[Download the paper](https://invitrolize.com/paper-methyl-methacrylate#2)

![Elsevier_MMA](https://invitrolize.com/hs-fs/hubfs/Elsevier_MMA.jpg?width=886&height=804&name=Elsevier_MMA.jpg)

#### Why This Study Matters.

- Methyl methacrylate (MMA) is widely used in industrial, medical, and dental applications
- Regulatory uncertainty persists due to unreliable human data and legacy test methods
- No validated tools have been available to identify respiratory sensitisation
- Critical need to distinguish irritation from true immune-mediated sensitisation
- This study closes that gap using a human-relevant, mechanistic in vitro approach

#### Key Results.

- MMA did not induce molecular or cellular signatures of respiratory sensitisation
- No activation of immune markers associated with AOP #39
- Transient stress responses at high doses were clearly separable from sensitisation
- Clear differentiation from known respiratory sensitizers

**Conclusion:** MMA should not be classified as a respiratory sensitizer.

#### Why ALIsens® Changes the Game.

- Human 3D in vitro reconstruction of the alveolar–capillary barrier
- Integrated epithelial, endothelial, and immune-relevant cell types
- Realistic air–liquid interface exposure
- Clear discrimination between irritation and sensitisation
- Designed for regulatory relevance and animal-free safety assessment

## Download the paper now

Access the full paper and review the scientific approach, validation process and results in detail.

Intended for professionals and research teams working in regulated environments.

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